Bio-Zelle GmbH is a German biotechnology corporation. For over three decades we involved in cultivation and growth of plant stem cells (plant callus cells) for exclusive clients and elite anti-ageing clinics worldwide.
Plants and animals might share cellular mechanisms that allow regeneration of tissues after damage. Animal and plant tissues wear out as part of normal physiological functions and can be lost to predators, disease, and injury. Both kingdoms survive this wide variety of insults by strategies that include the maintenance of adult stem cells or the induction of stem cell potential in differentiated cells.
Plant stem cells never undergo aging process but immortally give rise to new specialized and unspecialized cells, and they have the potential to grow into any organ, tissue, or cell in the body. Thus they are totipotent cells equipped with regenerative powers that facilitate plant growth and production of new organs throughout lifetime.
Plant cells are cultured to acquire plant useful compounds. However cell cultures are often hindered by various factors especially if cell culture continues long-term. However, strong vitality and structural characteristics of plant stem cell overcome previous drawbacks to plant cell culture. Thus plant stem cell culture is the most ideal and productive method of cell culture and phytochemical production as cells are successfully mass cultured while maintaining quality.
Callus, or dedifferentiated cells, are somatic cells that undergo dedifferentiation to give rise to totipotent embryogenic cells, which temporarily gains the ability to proliferate and/or regenerate an embryo. Since embryogenic cells were considered totipotent cells based on their ability to regenerate or develop into an embryo under given conditions, dedifferentiated cells were generally regarded as stem cells of plant. Callus exhibits a number of stem cell-like properties for a temporary period and that it has been cultured for useful plant compounds as an alternative source of plant stem cells. Callus is similar to plant stem cell in its ability to differentiate, but the two are different in their origin. While plant stem cell exists in the meristematic tissues of plant, callus is obtained as a temporary response to cure wound in somatic cell.
Stem cells are found in many organs of the adult human, including bone marrow, peripheral blood, umbilical cord blood, spleen, tooth pulp, and brain. These progenitor cells are being investigated for their potential use as transplanted tissues in the treatment of diseases such as cancer, diabetes, stroke, amyotrophic lateral sclerosis (ALS), and Parkinson’s disease. However, little effort is being directed toward enhancing the endogenous stem cells in the adult as an avenue to promote healing.
Hematopoietic stem cells (HSCs) have been investigated for many years for their utility in cancer treatments. Experimental investigations of hematopoiesis and clinical approaches to correcting its deficiencies have focused on cytokine activity. Cytokines modulate hematopoiesis by maintaining the self-renewal of stem cells and stimulating the proliferation and maturation of committed progenitor cells required for the continuous replacement of mature blood cells.
In vitro, various combinations of cytokines including interleukin-1 (IL-1), IL-3, IL-6, stem cell factor (SCF), and erythropoietin (EPO) have been found to support the growth of multi-potent progenitor cells. Individually, granulocyte–colony-stimulating factor (G-CSF) and EPO are growth factors for committed myeloid and erythroid progenitors, respectively. Clinically, G-CSF and EPO provide effective treatments for neutropenia and anemia and are used to enhance peripheral blood progenitors as an alternative to bone marrow transplantation for cancer patients. However, such treatments are costly and are not without certain risks. 
Certain naturally occurring nutrients could have important roles in maintaining the self-renewal of stem cells and stimulating the proliferation and differentiation of committed progenitors required for the continuous replacement of mature cells in the blood, brain, and other tissues. Furthermore, it may be possible to use certain natural products, either alone or synergistically, for the treatment of conditions where the stem cell replacement appears warranted.
Our 30-years research of dedifferentiated cells (callus) have demonstrated that various natural compounds and their combinations promote the proliferation of human bone marrow, human bone marrow-derived CD34, and human peripheral blood-derived CD133 cells as much as 40-60%, clearly promoting the growth of normal stem cells needed for healing while also reducing tumorgenicity potential.